Like other topical corticosteroids, halobetasol propionate has anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of the anti- inflammatory activity of the topical corticosteroids, in general, is unclear However, corticosteroids are thought to act by the induction of phospholipase A 2 inhibitory proteins , collectively called lipocorins It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid Arachidonic acid is released from membrane phospholipids by phospholipase A 2 .
Distribution : Following intravenous administration of 1 mg of fluticasone propionate in healthy volunteers, the initial disposition phase for fluticasone propionate was rapid and consistent with its high lipid solubility and tissue binding. The apparent volume of distribution averaged L/kg (range, - L/kg). The percentage of fluticasone propionate bound to human plasma proteins averaged 91%. Fluticasone propionate is weakly and reversibly bound to erythrocytes. Fluticasone propionate is not significantly bound to human transcortin.
For the off-season athlete there is no anabolic steroid more important or beneficial than testosterone. High levels of testosterone will promote significant increases in lean muscle mass and strength. This is assuming that the individual is consuming adequate calories. Compounds like Testosterone Propionate are not magical, you will still need to feed your body enough calories. During an off-season period of growth, this means total caloric intake will need to be slightly above maintenance. This will, unfortunately, promote body fat gain. However, the key to a successful off-season is gaining lean tissue while minimizing body fat gain to the fullest extent possible. By supplementing with Testosterone Propionate you will be able to achieve this more efficiently. High testosterone levels will promote a stronger metabolic rate. This is not a license to eat like there’s no end in sight, but you should be able to make better use of your calories.