Activated propionates

Valproic acid , and its derivatives such as sodium valproate and divalproex sodium , causes cognitive deficit in the child, with an increased dose causing decreased intelligence quotient . [77] On the other hand, evidence is conflicting for carbamazepine regarding any increased risk of congenital physical anomalies or neurodevelopmental disorders by intrauterine exposure. [77] Similarly, children exposed lamotrigine or phenytoin in the womb do not seem to differ in their skills compared to those who were exposed to carbamazepine. [77]

Ludwig Knorr was a student of Emil Fischer who won the Nobel Prize for his work on purines and sugars, which included the discovery of phenylhydrazine . [3] [13] In the 1880s, Knorr was trying to make quinolone derivatives from phenylhydrazine, and instead made a pyrazole derivative, which after a methylation, he made into phenazone , also called antipyrine, which has been called "the 'mother' of all modern antipyretic analgesics." [3] [14] :26–27 Sales of that drug exploded, and in the 1890s chemists at Teerfarbenfabrik Meister, Lucius & Co. (a precursor of Hoechst AG which is now Sanofi ), made another derivative called pyramidon which was three times more active than antipyrine. [3]

Activated propionates

activated propionates

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